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Title  Echa updates substance assessments under PACT
Source  Other
Date  2017-04-24 PM 3:54:53 Hit  455
Contents  Several suspected EDCs and CMRs undergoing RMOA
20 April 2017 / CMRs, EDCs, Europe, Sensitisers

Echa has included updates on 18 substances in its public activities coordination tool (PACT) for risk management option analysis (RMOA) or hazard assessment.
Seven substances have been added for which member states are now starting RMOA. The chemicals and suspected hazards or concerns are:
• alloys cobalt-tungsten carbide hard metals – suspected of being carcinogenic, mutagenic and reprotoxic (CMR), and suspected of specific target organ toxicity via repeat exposure (STOT RE);
• disodium octaborate (CMR);
• disodium peroxodisulphate – suspected of being a respiratory or skin sensitiser;
• persulfate ammonium (sensitiser);
• persulfate potassium (sensitiser);
• reaction product of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and phenol, heptyl derivatives – suspected endocrine disrupting chemical (EDC); and
• UVCB-diamines (STOT RE).
Member states have already carried out hazard assessments and are now undertaking RMOA on the following three substances, which they say are EDCs according to the WHO/IPCS definition:
• ammonium perchlorate;
• bisphenol A; and
• sodium perchlorate.
Evaluation of a further seven suspected EDCs is under development:
• 2-ethylhexyl trans-4-methoxycinnamate;
• 3,5,5-trimethylcyclohex-2-enone (isophorone);
• climbazole;
• dichloromethane;
• dicyclohexyl phthalate;
• diethylmethylbenzenediamine; and
• isopentyl p-methoxycinnamate.
And one is a potential EDC but the member state has postponed further assessment:
• (±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one (4-methylbenzylidenecamphor).
The member states carrying out work on their respective substances are Austria, Denmark, France, Germany, Italy, the Netherlands, Sweden and the UK.
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